Femara: Side Effects, Cost, Uses, and More

Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Female hormones that occur naturally in the body can increase the growth of some breast cancers. Letrozole works by decreasing the amounts of these hormones in the body. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Other drugs may affect letrozole, including prescription and over-the-counter medicines, vitamins, and herbal products.

Geriatric Patients

The reproductive performance of the male offspring was impaired at letrozole dose aslow as 0.003 mg/kg/day (approximately 0.01 times the maximum recommended human dose on a mg/m2 basis), as reflected bydecreased mating and pregnancy ratios. There were no effects on the reproductive performance of female offspring. Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of newfractures at any time after randomization was 13.3% for letrozole and 7.8% for placebo. The incidence of new osteoporosis was14.5% for letrozole and 7.8% for placebo. No dosage adjustment is recommended for patients with mild to moderate hepatic impairment, although Femara blood concentrationswere modestly increased in subjects with moderate hepatic impairment due to cirrhosis.

What should I do if I accidentally use too much letrozole?

A physiotherapist may also be able to suggest exercises to help. If you have secondary breast cancer, check with your specialist before starting any new type of exercise. For many people, side effects improve within the first few months of starting the treatment. However, for some people they may cause distress and disrupt everyday life. Many people living with cancer experience nausea, diarrhea and other symptoms from their treatment or disease.

In the extended adjuvant trial (MA-17), the incidence of bone fractures at any time after randomizationwas 13.3% for letrozole and 7.8% for placebo at a median follow-up of 62 months. The incidence of new osteoporosis was 14.5%for letrozole and 7.8% for placebo see ADVERSE REACTIONS. Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence ofcardiovascular disease at any time after randomization was 14.4% for letrozole and 9.8% for placebo. The extended adjuvant treatment trial (MA-17) was unblinded https://whatnextglobal.com/stanos-stanozolol-10-mg-elbrus-pharmaceuticals-18/ early see ADVERSE REACTIONS. At the updated (final analysis),overall the side effects seen were consistent to those seen at a median treatment duration of 24 months.

• Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
• The suppression of estrogen biosynthesis in peripheral tissuesand in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.
• These factors include what your insurance plan covers and which pharmacy you use.
• In the extended adjuvant setting, the reported drug-related adverse reactions that were significantly different from placebo were hot flashes, arthralgia/arthritis, and myalgia.

This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. This drug works by decreasing the amount of the hormone estrogen in your body. Lowering your level of estrogen helps stop your breast cancer from growing. Call your doctor right away if you have an allergic reaction to letrozole oral tablets. But if you think you’re having a medical emergency, call 911 or your local emergency number. Letrozole oral tablets are a generic drug, which means they’re an exact copy of the active drug in a brand-name medication.